SAFE Study

As the abortion pill heads back to the Supreme Court, advocates have a backup that’s effective and safe: misoprostol alone.

Nina Martin, Mother Jones
May 7, 2026

Medication abortion is back at the US Supreme Court—which is exactly where abortion opponents want it. Last week, in a late Friday afternoon move guaranteed to stoke maximum confusion and panic, the Fifth Circuit Court of Appeals blocked a Food and Drug Administration rule allowing telemedicine prescription of mifepristone, one of two drugs that make up the gold-standard abortion-pill regimen. On Monday morning, Supreme Court Justice Samuel Alito put that ruling on pause until May 11.

But even as abortion advocates expressed relief that telemedicine abortions can continue for a few more days, the order by Alito—the same ultraconservative who wrote the Dobbs decision overturning Roe v. Wade in 2022—was at best a reprieve. At some point soon, the court’s right-wing supermajority could drastically curtail or cut off access by mail to an extremely safe and effective drug that has been used by hundreds of thousands of women a year since Dobbs, including in states where abortion is banned. Almost two-thirds of abortions in the US now happen with pills, and nearly 30 percent occur by telemedicine.

Continued; https://www.motherjones.com/politics/2026/05/they-came-for-mifepristone-the-abortion-rights-movement-is-ready/

Mifepristone’s future is shaky—but women and pregnant people can still access misoprostol, a highly effective and medically safe method to end an early pregnancy.

2/14/2023
by CARRIE N. BAKER, Ms. Magazine

Over half of clinician-supervised abortions in the U.S. in 2020 were done with a combination of two medications: mifepristone and misoprostol. A Trump-appointed judge in Texas will soon decide a lawsuit brought by anti-abortion extremists asking him to force mifepristone off the market in all 50 states. If he does, as anticipated, reproductive rights advocates are ready to offer a safe and effective alternative to end pregnancy through three months: a higher dosage of misoprostol taken alone.

Misoprostol is a widely available ulcer medication that can induce a miscarriage by causing contractions of the uterus to expel a pregnancy. In the 1980s, Brazilian women began using misoprostol to end their pregnancies because abortion was unavailable through the medical system. Self-managed abortion with misoprostol resulted in precipitous declines in infection, hemorrhaging and death from unsafe abortion.

Continued: https://msmagazine.com/2023/02/14/misoprostol-abortion/

USA – They Came for Mifepristone. The Abortion Rights Movement Is Ready.

As Conservatives Try to Ban the Abortion Pill Mifepristone, New Research Shows Accessible Ulcer Drug Safely Ends Pregnancy Up to 12 Weeks